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The sequence file is generated by a program after a series of related images is taken. It is the application programmers choice when to break a sequence of images, but it is logical to allow that if a discrete set of images of the same exposure time are specified they should go into their own .seq file.
The seq file contains a set of file names followed by the '/' delimiter. A program parsing the .seq file might simply count the number of delimiters in the file to determine the number of files. This leads to the generation of a sequence meta file or the processing of a sequence by a users program, or the sequence file is read once to determine the allocation of memory for image buffers, then the buffers are read into the reduction program.